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Causes

The Causes Of Genitourinary Inflammation and Prostate Disease

Chronic genitourinary inflammation and prostate diseases are usually caused by pathogens (especially biofilm formation) , pathogenic factor, and toxic compounds.

The most common pathogens include two types of bacterial and non-bacterial ones. The most common bacterial pathogens are staphylococcus,streptococcus, enterococcus, escherichia coli, corynebacterium, proteus, klebsiella, etc. The most common non-bacterial pathogens are virus, chlamydia, mycoplasma, fungus, and parasites, etc.

Bacterial biofilm is an architectural colony of microorganisms. The process of biofilm formation consists of many steps, starting with attachment to a living or non-living surface that will lead to formation of micro-colony, giving rise to three-dimensional structures and ending up, after maturation, with detachment. During formation of biofilm several species of bacteria communicate with one another, employing quorum sensing. In general, bacterial biofilms show resistance against human immune system, as well as against antibiotics. Among all intractable genitourinary inflammation and prostate diseases, most are related to the formation of biofilms.

pathogenic factor include inflammatory cytokines (such as TNF-α, IL-1, IL-6, IL-8, etc) and inflammatory mediator (such as histamine, bradykinin, prostaglandins, oxygen free radicals and lysosomal enzymes, etc.). These pathogenic factor damages normal tissue cells and plays an important role in the development of chronic genitourinary inflammation and prostate diseases.

Toxic compounds refers to harmful chemicals in the human body. Toxic compounds is divided into exotoxin and endotoxin. Exotoxin refers to environment pollution brings harmful chemicals, such as, air pollution, water pollution, and food pollution. Endotoxin refers to harmful chemicals created in the human body during the process of metabolism. These harmful chemicals include lactic acid, ketone acid, uric acid, and free radicals. Toxic compounds also includes biological toxins produced by pathogens, excess fat, and old and dead cells in the human body.

The pathogenic pathogens, pathogenic factor, and toxic compounds cause direct damage to the healthy cells, tissues, and organs. Over time, this can lead to DNA damage, tissue cells death, and internal scarring. Chronic inflammation can form various diseased areas that are not easy to cure, such as blockages, calcifications, fibrosis, granuloma, ulcers, etc. All of these are linked to the development of intractable genitourinary inflammation and prostate diseases.

   

The Common Pathogens Of Genitourinary Inflammation and Prostate Disease

We found that all chronic genitourinary inflammation and prostate diseases in the development process, there are one or more specific pathogens.

Non-communicable pathogens (such as Staphylococcus, Streptococcus, Enterococcus, etc.) usually spread from other parts of the body (such as the upper respiratory tract and intestine) to the genitourinary tract and prostate through blood and lymphatic routes. Infectious pathogens (such as pathogens of sexually transmitted diseases, viruses, etc) usually spread from the urethra or vagina to the genitourinary tract and prostate through direct transmission.

The causative pathogens release a variety of toxins, direct damage to the genitourinary tract and prostate cells, produces a variety of pathological cells, compromise gland function, and the quality of semen. The prostate and vas deferens tubes become blocked, and calcification form. Overtime the genitourinary tract and prostate formed a variety of pathological tissues, Such as infected tissue, hyperplastic tissue, and cancerous tissue, etc.

The most common pathogens include two types of bacterial and non-bacterial. The most common bacterial pathogens are staphylococcus,streptococcus, enterococcus, escherichia coli, corynebacterium, proteus, klebsiella, etc. The most common non-bacterial pathogens are virus, chlamydia, mycoplasma, fungus, and trichomonas, etc.

1) Causative gram-negative bacteria include: Escherichia coli, Proteus, Pseudomonas aeruginosa, and Neisseria gonorrhoeae, etc. Causative gram-positive bacteria include:Staphylococcus haemolyticus, Streptococcus viridans (SV), Corynebacterium, etc. These bacteria are the most common bacteria that cause chronic genitourinary inflammation and prostate diseases.

2) Anaerobic bacteria (anaerobicbacteria) is a kind of bacteria that grow better under anaerobic conditions than in aerobic environment, it is widely exists in the deep mucosal surface of skin and cavities. Because of the genitourinary tract and prostate are close to the rectum and anus, can be easily infected by anaerobic bacteria.

3) Fungus includes Candida and Yeast. According to the areas which been infected by fungus, fungal infection can be divided into superficial fungal disease and deep fungal disease. Deep fungal disease can invade the human skin, mucous membranes, deep tissue and internal organs, and even cause systemic disseminated infection, and the causative pathogen is mainly Candida albicans (candida Albicans). Candida albicans is the most common pathogen that causes chronic genitourinary inflammation and prostate diseases.

4) There are three type of Chlamydia, Chlamydia trachomatis, Chlamydia pneumoniae and Chlamydia psittaci. Chlamydia trachomonatis is one of the most common sexually transmitted pathogens and it is also one of the most common causes of chronic genitourinary inflammation and prostate diseases. In males, Chlamydia causes urethritis, prostatitis, epididymitis, sperm damage, and infertility, etc. In females, Chlamydia causes cervicitis, endometritis, uterine inflammation, hydrosalpinx, tubal scarring, fallopian tube obstruction, natural abortion, tubal pregnancy, and infertility, etc.

5) Among mycoplasma, Mycoplasma hominis, Ureaplasma urealyticum and genital mycoplasma are main causes of chronic genitourinary inflammation and prostate diseases. Ureaplasma urealyticum causes urethritis, cervicitis, pelvic inflammatory disease PID, endometritis, salpingitis, epididymitis and prostatitis.

6) Some types of virus can cause chronic genitourinary inflammation and prostate diseases, such as human papilloma virus (HPV),Cytomegalovirus (CMV), Coxsackie Virus ( CSV) and Herpes Simplex Virus (HSV). Virus will weaken immunity, and easily combined with other pathogen infection. Virus can damage the urogenital organs directly, and may result in prostate cancer.


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